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For significant deficiencies, injections might be administered more frequently at the start (e.g., weekly), and once levels stabilize, the frequency can be reduced (e.g., monthly)
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Exposure of pregnant rats to FBs impairs bone metabolism of the offspring via alteration of the osteoprotegerin (OPG)-to-RANκL (receptor activator of nuclear factor κB ligand), possibly driven by immunological alterations (153), and by affecting the expression of remodeling enzymes [MMPs and their tissue inhibitors (TIMPs)] and angiogenic factors [vascular endothelial growth factor (VEGF)] (154)
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